Product Description
SOCS1 Antibody | 13-289 | ProSci
Host: Rabbit
Reactivity: Mouse, Rat
Homology: N/A
Immunogen: A synthetic peptide of human SOCS1
Research Area: Cell Cycle, Immunology, Signal Transduction
Tested Application: WB, IHC, IF, Flow
Application: WB: 1:500 - 1:1000
IHC: 1:50 - 1:200
IF: 1:20 - 1:50
Flow: 1:20 - 1:50
Specificiy: N/A
Positive Control 1: Mouse thymus
Positive Control 2: Mouse lung
Positive Control 3: Mouse skin
Positive Control 4: Rat thymus
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 26kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, pH7.3.
Concentration: N/A
Storage Condition: Store at 4˚C. Avoid freeze / thaw cycles.
Alternate Name: SOCS1 Antibody: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a member of the STAT-induced STAT inhibitor (SSI) , also known as suppressor of cytokine signaling (SOCS) , family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO) , CSF2/GM-CSF, and interferon (IFN) -gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.