Product Description
VIMP Antibody | 15-831 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human VIMP (NP_982298.2) .
Research Area: Immunology, Innate Immunity, Signal Transduction
Tested Application: WB
Application: WB: 1:500 - 1:2000
Specificiy: N/A
Positive Control 1: 293T
Positive Control 2: A-431
Positive Control 3: Mouse brain
Positive Control 4: Rat lung
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 21kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: SELS, AD-015, ADO15, MGC104346, MGC2553, SBBI8, SEPS1, VIMP, SELS
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER) . It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) . Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR have been shown to function as modulators of Sec insertion in this protein (PMID:23614019) . An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene.