Product Description
Anti CD146/MUC18 (c3.19.1) Antibody, Monoclonal | 21-877 | ProSci
Product Type: Primary Antibodies
Category: Primary Antibodies, Monoclonal Antibodies
Research Area: Drug Analogues
Type: Monoclonal
Host Species: N/A
Reactivity Species: N/A
Homology: N/A
Immunology: Humanized / CD146/MUC18 [Homo sapiens]
Tested Application: N/A
Application Note: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Predicted Molecular Weight: N/A
Isoform: N/A
Purification: >95%
Clonality: Recombinant Monoclonal
Clone: N/A
Isotype: Human IgG2
Conjugate: Unconjugated
Physical State: N/A
Buffer: PBS buffer pH 7.5
Concentration: N/A
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4°C short term (1-2 weeks) . Store at -20 °C 12 months. Store at -80°C long term.
Additional Names: c3.19.1, CD146; MUC18; HEMCAM; METCAM; MelCAM
Protein Accession: P43121
User Note: For research use only .
Background: c3.19.1refers to a fully human IgG2 monoclonal antibody directed against the MUC18 antigen. The antibody was generated using XenoMouse® technology (Abgenix, Inc. Fremont, Calif.) and consists of human gamma 2 heavy and kappa light chains with a molecular weight of approximately 150 kDa. CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
Loading Controls: N/A
Source: XtenCHO
Purity: >95%
CAS: N/A
Shipping Condition: N/A