Product Description
BCL10 Antibody [4F8E8H8] | 32-115 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3) .
Research Area: Signal Transduction, Apoptosis
Tested Application: E, WB, IHC
Application: IHC (P) :Dilution 1:1, 000 - 1:2, 000
IHC (F) :Dilution 1:1, 000 - 1:2, 000
Western blot:Dilution 1:2, 000 - 1:5, 000
ELISA:Propose dilution 1:10, 000.
Determining optimal working dilutions by titration test.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Antibody is purified by protein A affinity chromatography.
Clonality: Monoclonal
Clone: 4F8E8H8
Isotype: IgG1
Conjugate: Unconjugated
Physical State: N/A
Buffer: N/A
Concentration: N/A
Storage Condition: BCL-10 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: CIPER, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10, mE10, CIPER, c-E10, CARMEN
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: B-cell CLL/lymphoma 10, also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD) . It plays an important role in apoptosis and activating NF-κB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-κB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-κB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.