Product Description
CD117 Antibody [YB5.B8] (PE) | 76-905 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: N/A
Research Area: Stem Cell
Tested Application: Flow
Application: N/A
Specificiy: The YB5.B8 monoclonal antibody specifically binds with human CD117 (c-kit) , the 145 kDA receptor for stem cell factor (SCF) or steel factor.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality: Monoclonal
Clone: YB5.B8
Isotype: Mouse IgG1, kappa
Conjugate: PE
Physical State: liquid
Buffer: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration: batch dependent
Storage Condition: The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.
Alternate Name: PBT, SCFR, C-Kit, CD117, KIT
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The YB5.B8 monoclonal antibody specifically binds with human CD117 (c-kit) , the 145 kDA receptor for stem cell factor (SCF) or steel factor. This tyrosine kinase protein is expressed mainly on hematopoietic progenitor, mast cells, acute myeloid leukemia cells (AML) . CD117 activation promotes proliferation and cell differentiation on these cell subtypes. A lack or defect of SCF can lead to a decrease in number of hematopoietic progenitor cells and severe anemia.