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![CDK4 Antibody [3F6A4]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/572594/805742/porsci_lo__79508.1648973713__77455.1649090930.png?c=2 "CDK4 Antibody [3F6A4]")
![CDK4 Antibody [3F6A4]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/572594/805742/porsci_lo__79508.1648973713__77455.1649090930.png?c=2 "CDK4 Antibody [3F6A4]")
Product Description
CDK4 Antibody [3F6A4] | 13-006 | ProSci
Host: Mouse
Reactivity: Human, Mouse
Homology: N/A
Immunogen: Recombinant protein of human CDK4
Research Area: Cancer, Cell Cycle, Signal Transduction
Tested Application: WB, IHC
Application: WB: 1:500 - 1:1000
IHC: 1:20 - 1:50
Specificiy: N/A
Positive Control 1: A-431
Positive Control 2: HeLa
Positive Control 3: NIH/3T3
Positive Control 4: Mouse thymus
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 34kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Monoclonal
Clone: [3F6A4]
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, pH7.3.
Concentration: N/A
Storage Condition: Store at 4˚C. Avoid freeze / thaw cycles.
Alternate Name: CDK4, CMM3, PSK-J3
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
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