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![Beta Catenin Antibody [12F7]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/575419/812103/porsci_lo__79508.1648973713__39521.1649091919.png?c=2 "Beta Catenin Antibody [12F7]")
![Beta Catenin Antibody [12F7]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/575419/812103/porsci_lo__79508.1648973713__39521.1649091919.png?c=2 "Beta Catenin Antibody [12F7]")
Product Description
Beta Catenin Antibody [12F7] | 33-590 | ProSci
Host: Mouse
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: A recombinant fusion protein consisting of the N-terminal half of human beta-Catenin fused to maltose binding protein was used as the immunogen for the Beta Catenin antibody.
Research Area: Cancer, Neuroscience, Signal Transduction
Tested Application: Flow, IF, WB
Application: Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Immunofluorescence: 1-2 ug/ml
WB: 1-2 ug/ml
Titration of the Beta Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Protein G affinity chromatography
Clonality: Monoclonal
Clone: 12F7
Isotype: IgG1, kappa
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
Alternate Name: Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
User Note: Optimal dilutions for each application to be determined by the researcher
BACKGROUND: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC) , pilomatrixoma (PTR) , medulloblastoma (MDB) , and ovarian cancer. [RefSeq]
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