Product Description
Beta III Tubulin Antibody [AA10] | 50-261 | ProSci
Host: Mouse
Reactivity: Mammal
Homology: N/A
Immunogen: Synthetic peptide corresponding to beta III tubulin.
Research Area: Homeostasis
Tested Application: WB, IHC
Application: N/A
Specificiy: Specific for the ~55kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 55
Validation: N/A
Isoform: N/A
Purification: Protein G purified
Clonality: Monoclonal
Clone: AA10
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: N/A
Concentration: N/A
Storage Condition: Beta III Tubulin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Alternate Name: N/A
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990) . Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)