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![FSH Receptor Antibody [FSHR/1400]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/575504/812310/porsci_lo__79508.1648973713__45143.1649091945.png?c=2 "FSH Receptor Antibody [FSHR/1400]")
![FSH Receptor Antibody [FSHR/1400]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/575504/812310/porsci_lo__79508.1648973713__45143.1649091945.png?c=2 "FSH Receptor Antibody [FSHR/1400]")
Product Description
FSH Receptor Antibody [FSHR/1400] | 33-686 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: A human recombinant protein was used as the immunogen for this FSHR antibody.
Research Area: Other
Tested Application: Flow, IHC, IF
Application: Flow Cytometry: 0.5-1ug/10^6 cells
IF: 1-2 ug/ml
IHC (FFPE) : 1-2 ug/ml for 30 min at RT
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FSHR antibody to be titered up or down for optimal performance.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Protein G affinity chromatography
Clonality: Monoclonal
Clone: FSHR/1400
Isotype: IgG1, kappa
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
Alternate Name: FSHR, Follitropin receptor, FSHRO, Ovarian dysgenesis 1, FSH receptor, FSH-R, LGR1, ODG1
User Note: Optimal dilutions for each application to be determined by the researcher
BACKGROUND: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG) . In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
![FSH Receptor Antibody [FSHR/1400]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/575504/812310/porsci_lo__79508.1648973713__45143.1649091945.png?c=2 "FSH Receptor Antibody [FSHR/1400]")
