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Product Description
KSHVORF62 Antibody [5B7B6] | 32-229 | ProSci
Host: Mouse
Reactivity: Virus
Homology: N/A
Immunogen: Ni-NTA purified recombinant human KSHV ORF62 expressed in E. Coli strain BL21 (DE3) .
Research Area: Infectious Disease
Tested Application: WB
Application: Western Blot:1:500 - 1, 000
ELISA:Determining optimal working dilutions by titration test.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: 5B7B6
Isotype: IgM
Conjugate: Unconjugated
Physical State: N/A
Buffer: Ascitic fluid containing 0.03% sodium azide.
Concentration: N/A
Storage Condition: to KSHV ORF62 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: Triplex capsid protein VP19C homolog
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2) -herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17) , the major capsid protein (encoded by ORF25) , and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65) . Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
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