Product Description
P-Cadherin Antibody [12H6] | 33-693 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: A human full length recombinant protein was used as the immunogen for this P-Cadherin / CDH3 antibody.
Research Area: Cancer, Neuroscience, Signal Transduction
Tested Application: WB, IF
Application: IF: 1-2 ug/ml
WB: 1-2 ug/mll
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CDH3 antibody to be titered up or down for optimal performance.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Protein G affinity chromatography
Clonality: Monoclonal
Clone: 12H6
Isotype: IgG1, kappa
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
Alternate Name: Cadherin-3, Placental cadherin, P-cadherin, CDH3, CDHP
User Note: Optimal dilutions for each application to be determined by the researcher
BACKGROUND: Recognizes a protein of 116kDa, identified as P-Cadherin, or Cadherin 3 or CDH3. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy.