Product Description
TIMP-4 Antibody [SB30c] | 99-775 | ProSci
Host: Mouse
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant human TIMP-4 (a.a. 35-224)
Research Area: Cancer, Cell Cycle
Tested Application: E
Application: TIMP-4 Antibody [SB30c] for use in immunocytochemistry, ELISA, and western blotting assays.
Specificiy: TIMP-4
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [SB30c]
Isotype: IgG2a
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Tissue inhibitor of metalloproteinase 4
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs) . TIMPs play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4, unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast, and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation.