Product Description
VLDLR Antibody [VLDLR/1337] | 33-746 | ProSci
Host: Mouse
Reactivity: Human, Rat
Homology: N/A
Immunogen: A human recombinant partial protein from the C-terminal region was used as the immunogen for this VLDL Receptor antibody.
Research Area: Cancer, Obesity, Neuroscience, Signal Transduction
Tested Application: WB, Flow, IF, IHC-P
Application: Flow Cytometry: 0.5-1ug/10^6 cells in 0.1ml
IF: 1-2 ug/ml
Western blot: 1-2 ug/ml
IHC (FFPE) : 1-2 ug/ml for 30 min at RT
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the VLDL Receptor antibody to be titered up or down for optimal performance.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Protein G affinity chromatography
Clonality: Monoclonal
Clone: VLDLR/1337
Isotype: IgG1
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
Alternate Name: Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR
User Note: Optimal dilutions for each application to be determined by the researcher
BACKGROUND: Very Low Density Lipoprotein Receptor (VLDLR/VLDL receptor) is a member of the LDL receptor gene family which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF) -like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDL receptor is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein) , which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.