Product Description
PEK/PERK (phospho Thr982) Antibody | 79-862 | ProSci
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: PEK/PERK (phospho Thr982) antibody was raised against a peptide sequence around phosphorylation site of threonine 981 (A-R-H (p) -T-G) derived from Human PEK/PERK.
Research Area: Phospho-Specific
Tested Application: IHC
Application: N/A
Specificiy: The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 125 kDa
Validation: N/A
Isoform: N/A
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Condition: Store antibody at -20˚C for up to one year.
Alternate Name: E2AK3, PERK, PEK, EIF2AK3
User Note: N/A
BACKGROUND: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) , leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)