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Product Description
CD137 Antibody | 36-216 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: Human CD137.
Research Area: Cancer, Immunology
Tested Application: Flow, WB
Application: Flow Cytometry: (1:500-1:1, 000) . Western Blot: (1:2, 000-1:5, 000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 with 5% skim milk. Suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.
Specificiy: Recognizes human CD137. Detects a band of ~29kDa by Western blot. Does not cross-react with mouse CD137.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Polyclonal
Clone: N/A
Isotype: N/A
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration: 1 mg/ml
Storage Condition: Stable for at least 6 months after receipt when stored at -20˚C.
Alternate Name: 4-1BB; TNFRSF9
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD137 is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.
