Euro
USD
British Pound
NULL
Product Description
Tau (phospho Ser416) Antibody | 50-270 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat, Bovine, Chicken
Homology: N/A
Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser416 of rat tau.
Research Area: Neuroscience, Phospho-Specific
Tested Application: WB
Application: N/A
Specificiy: Specific for ~59, 65, 68k tau protein phosphorylated at Ser416.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 59/65/68
Validation: N/A
Isoform: N/A
Purification: Affinity Purified
Clonality: Polyclonal
Clone: N/A
Isotype: N/A
Conjugate: Unconjugated
Physical State: Liquid
Buffer: N/A
Concentration: N/A
Storage Condition: Tau (Ser416) antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Alternate Name: N/A
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985) . Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990) . Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD) , Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995) . Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990) .
![Phospho-Tau (Ser416) [Ser733] Antibody | AF2420](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/900566/1192780/aff-logo__47674.1661174492__95755.1661185535.png?c=2 "Phospho-Tau (Ser416) [Ser733] Antibody | AF2420"){kind=logo}
