Product Description
GPI Antibody | 19-202 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: A synthetic peptide of human GPI
Research Area: Cancer, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Neuroscience, Signal Transduction
Tested Application: WB, Flow
Application: WB: 1:500 - 1:1000
Flow: 1:20 - 1:50
Specificiy: N/A
Positive Control 1: Rat liver
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 60kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, pH7.3.
Concentration: N/A
Storage Condition: Store at 4˚C. Avoid freeze / thaw cycles.
Alternate Name: Neuroleukin, sperm antigen-36, phosphosaccharomutase, phosphohexose isomerase, phosphohexomutase, phosphoglucose isomerase, oxoisomerase, neuroleukin, hexosephosphate isomerase, hexose monophosphate isomerase, glucose-6-phosphate isomerase, autocrine motility factor, SA-36, PGI, NLK, GNPI, AMF, glucose phosphate isomerase, GPI, PHI, SA36
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.