Product Description
CD107a Antibody [1D4B] | 99-109 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: Plasma membrane fraction of mouse embryo NIH/3T3 cell line
Research Area: Innate Immunity
Tested Application: IHC-Fr, ICC, Flow, IP, Separation
Application: CD107a Antibody [1D4B] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, ELISA, and purification assays.
Specificiy: CD107a
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [1D4B]
Isotype: IgG2a
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: LAMP-1, lysosomal-associated membrane protein 1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1) , is a heavily glycosylated type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and beige mutant mice. It may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases.