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![CD11b Antibody [3A33]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576471/814281/porsci_lo__79508.1648973713__39115.1649092206.png?c=2 "CD11b Antibody [3A33]")
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Product Description
CD11b Antibody [3A33] | 98-632 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: Peritoneal macrophages from B6D2 hybrid mice
Research Area: Immunology, Neuroscience, Signal Transduction
Tested Application: E, IHC-Fr, ICC, Flow
Application: CD11b Antibody [3A33] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays.
Specificiy: CD11b
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [3A33]
Isotype: IgG2a
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD11b (integrin alphaM subunit) combines with CD18 (integrin beta2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3) , which mediates adhesion to C3bi and ICAM-1 (CD54) . Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.
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