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Product Description
CD19 Antibody [6D5] (PE-Cy7) | 98-666 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: Mouse CD19-expressing K562 human erythroleukemia cells
Research Area: Immunology
Tested Application: E, WB, ICC
Application: CD19 Antibody [6D5] for use in flow cytometry assays.
Specificiy: CD19
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [6D5]
Isotype: IgG2a
Conjugate: PE-Cy7
Physical State: Liquid
Buffer: Supplied in PBS/NaN3 and a stabilizing agent
Concentration: 0.1 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: B4, Leu-12
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1) , and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. Studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. The monoclonal antibody 6D5 recognizes the same epitope as the published clone, 1D3.
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