Product Description
Recombinant SARS-CoV-2 (COVID-19) S1 Antibody [5D9] | 93-311 | ProSci
Host: Human
Reactivity: Virus
Homology: N/A
Immunogen: full length recombinant S Protein
Research Area: Infectious Disease, COVID-19
Tested Application: E
Application: Immunoreactivity: 80–120 % compared to the reference sample in an ELISA test.
Specificiy: Antibody recognizes 2019-nCoV S1 Protein/ 2019-nCoV S-RBD Protein.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: ≥95 %
Clonality: Recombinant Monoclonal
Clone: 5D9
Isotype: Human IgG1
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS, pH 7.4
Concentration: 2.0 mg/ml (+/- 10 %)
Storage Condition: 24 months from manufacturing at <-20 ˚C; 1 month, 2 to 8 ˚C under sterile conditions.
Alternate Name: SARS-CoV-2 (COVID-19) Spike S1 Antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) , Surface Glycoprotein, Spike protein
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS) . The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD) , which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.