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Product Description
A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. Also recently shown to improve the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells 2-fold.
8-Br-cAMP is a cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.
Biovision | 1837 | 8-Br-cAMP DataSheet
Alternate Name/Synonyms: 8- Bromoadenosine- 3', 5'- cyclic monophosphate; cyclic 8- bromoadenosine- 3', 5'- monophosphate; 8- bromoadenosine- 3', 5'-Monophosphate
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 76939-46-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₀H₁₀BrN₅O₆P. Na
Molecular Weight: 430.08
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: H₂O (~100 mg/ml)
Handling: Protect from moisture and light
Country of Origin: USA
Tag Line: A PKA activator
MDL Number: MFCD00005844
PubChem CID: 23712387
SMILES: C1C2C(C(C(O2)N3C4=C(C(=NC=N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]
InChi: InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3 (21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13, 14);/q;+1/p-1
InChi Key: DMRMZQATXPQOTP-UHFFFAOYSA-M
