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Product Description
A L-type calcium channel blocker and an anti-hypertensive agent. Amlodipine displays vasoprotective effects in cardiovascular disease and inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM). Amlodipin also inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).
Amlodipine is a L-type calcium channel blocker and an anti-hypertensive agent.
Biovision | 2378 | Amlodipine besylate DataSheet
Alternate Name/Synonyms: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
Appearance: White solid
Formulation: N/A
CAS Number: 111470-99-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₅ClN₂O₅.C₆H₆O₃S
Molecular Weight: 567.05
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~100 mM) or H₂O (~10 mM)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A calcium channel blocker
MDL Number: MFCD00887594
PubChem CID: 60496
SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
InChi: InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChi Key: ZPBWCRDSRKPIDG-UHFFFAOYSA-N
