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Product Description
AR-42 is a potent histone deacetylase inhibitor (HDACi). It induces growth inhibition, cell- cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 also promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21 and exhibits in vitro and ex vivo biologic activity against malignant mast cells.
AR-42 is a potent histone deacetylase inhibitor (HDACi). It induces growth inhibition, cell- cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 also promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21 and exhibits in vitro and ex vivo biologic activity against malignant mast cells.
Biovision | 2716 | AR-42 (HDAC-42) DataSheet
Alternate Name/Synonyms: S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 935881-37-1
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₂₀N₂O₃
Molecular Weight: 312.36
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 20 mg/ml) or EtOH (~ 20 mg/ml
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent HDAC inhibitor
MDL Number: MFCD17676151
PubChem CID: 6918848
SMILES: CC(C)C(C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO
InChi: InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1
InChi Key: LAMIXXKAWNLXOC-INIZCTEOSA-N
