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Product Description
Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC₅₀ = 11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC₅₀ in the range of 7-410 nM). May be effective in dementia.
Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC₅₀ = 11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC₅₀ in the range of 7-410 nM). May be effective in dementia.
Biovision | B1824 | Arecoline hydrobromide DataSheet
Alternate Name/Synonyms: 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide
Appearance: White solid
Formulation: N/A
CAS Number: 300-08-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₈H₁₃NO₂ • HBr
Molecular Weight: 236.11
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: H₂O (>50 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A covalent ACAT1 inhibitor
MDL Number: MFCD00039041
PubChem CID: 9301
SMILES: CN1CCC=C(C1)C(=O)OC.Br
InChi: InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
InChi Key: AXOJRQLKMVSHHZ-UHFFFAOYSA-N
