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Product Description
BAY-1436032 is a potent and highly selective inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations.
BAY-1436032 is a potent and highly selective inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations.
Biovision | B1570 | BAY-1436032 DataSheet
Alternate Name/Synonyms: 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1803274-65-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₆H₃₀F₃N₃O₃
Molecular Weight: 489.5
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and highly selective inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1)
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(O)CCC1=CC=C2N([C@H]3CC(C)(C)C[C@@H](C)C3)C(NC4=CC=C(OC(F)(F)F)C=C4)=NC2=C1
InChi: InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)/t16-,19+/m0/s1
InChi Key: RNMAUIMMNAHKQR-QFBILLFUSA-N
