Product Description
BAY-1125976 is a potent and selective allosteric AKT1/2 inhibitor that displays high efficacy on AKT signaling-dependent tumor growth in mouse models. It inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
BAY-1125976 is a potent and selective allosteric AKT1/2 inhibitor that displays high efficacy on AKT signaling-dependent tumor growth in mouse models. It inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
Biovision | B3268 | BAY-1125976 DataSheet
Alternate Name/Synonyms: BAY1125976 Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
Appearance: Crystalline solid
Formulation:
CAS Number: 1402608-02-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₁N₅O
Molecular Weight: 383.45
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities:
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective allosteric AKT1/2 inhibitor
MDL Number:
PubChem CID: 70817911
SMILES: O=C(C1=NN2C(C=C1)=NC(C3=CC=C(C4(N)CCC4)C=C3)=C2C5=CC=CC=C5)N
InChi: InChI=1S/C23H21N5O/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23/h1-3,5-12H,4,13-14,25H2,(H2,24,29)
InChi Key: JBGYKRAZYDNCNV-UHFFFAOYSA-N