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Product Description
Ac-IEPD-AFC is a useful fluorogenic substrate for the detection of Granzyme B. Granzyme B activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at 400 nm and emission maximum at 505 nm.
Ac-IEPD-AFC is a useful fluorogenic substrate for the detection of Granzyme B.
Biovision | B2526 | Ac-IEPD-AFC DataSheet
Alternate Name/Synonyms: Granzyme B substrate; Ac-Ile-Glu-Pro-Asp-AFC; N-Acetyl-Ile-Glu-Pro-Asp-(7-amino-4-trifluoromethylcoumarin)
Appearance: White to off-white solid
Formulation:
CAS Number: 1135417-31-0
Structure Available?: Yes
Peptide sequence: Ac-IEPD-AFC
Salt Form: No
Molecular Formula: C₃₂H₃₈F₃N₅O₁₁
Molecular Weight: 725.67
Cell-Permeable?: True
Purity: ≥95% by HPLC
Solubilities: >14 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A fluorogenic Granzyme B substrate
MDL Number: MFCD03452821
PubChem CID: 25108575
SMILES: CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)N1CCCC1C(=O)NC(CC(=O)O)C(=O)NC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F)NC(=O)C
InChi: InChI=1S/C32H38F3N5O11/c1-4-15(2)27(36-16(3)41)30(49)38-20(9-10-24(42)43)31(50)40-11-5-6-22(40)29(48)39-21(14-25(44)45)28(47)37-17-7-8-18-19(32(33,34)35)13-26(46)51-23(18)12-17/h7-8,12-13,15,20-22,27H,4-6,9-11,14H2,1-3H3,(H,36,41)(H,37,47)(H,38,49)(H,39,48)(H,42,43)(H,44,45)/t15-,20-,21-,22-,27-/m0/s1
InChi Key: HWXKKVLJPWMVLL-FGGUPADCSA-N
