Product Description
Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, that is used as an antiinflammatory drug in development for the treatment of CF and other diseases. Leukotriene A4 hydrolase (LTA4H) catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils.
Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, that is used as an antiinflammatory drug in development for the treatment of CF and other diseases. Leukotriene A4 hydrolase (LTA4H) catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils.
Biovision | B3206 | Acebilustat DataSheet
Alternate Name/Synonyms: CTX4430,4-(((1S,4S)-5-(4-(4-(oxazol-2-yl)phenoxy)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)benzoic acid,EP501,ZK322
Appearance: Crystalline solid
Formulation:
CAS Number: 943764-99-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₂₇N₃O₄
Molecular Weight: 481.55
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: >15 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective leukotriene A4 hydrolase inhibitor
MDL Number:
PubChem CID: 68488178
SMILES: O=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1
InChi: InChI=1S/C29H27N3O4/c33-29(34)23-5-1-20(2-6-23)16-31-18-25-15-24(31)19-32(25)17-21-3-9-26(10-4-21)36-27-11-7-22(8-12-27)28-30-13-14-35-28/h1-14,24-25H,15-19H2,(H,33,34)/t24-,25-/m0/s1
InChi Key: GERJIEKMNDGSCS-DQEYMECFSA-N