Product Description
Acefylline is a xanthine derivative which acts as potential Peptidylarginine deiminase (PAD) activator. It increases the in vitro deimination of filaggrin by PAD1 and PAD3 at a concentration of 200 μM. It enhances deimination in the stratum corneum which is essential for epidermal photoprotection and moisturizing of the stratum corneum. Acefylline is also a bronchodilator, which inhibits rat lung cAMP phosphodiesterase isoenzymes.
Acefylline is a xanthine derivative which acts as potential Peptidylarginine deiminase (PAD) activator. It increases the in vitro deimination of filaggrin by PAD1 and PAD3 at a concentration of 200 μM. It enhances deimination in the stratum corneum which is essential for epidermal photoprotection and moisturizing of the stratum corneum. Acefylline is also a bronchodilator, which inhibits rat lung cAMP phosphodiesterase isoenzymes.
Biovision | B3119 | Acefylline DataSheet
Alternate Name/Synonyms: Theophylline-7-acetic acid; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid; 7-(Carboxymethyl)theophylline; (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid; 2-(1,3-Dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetic acid; 1,3-Dimethylxanthine-7-acetic acid; 2-(1,3-dimethyl-2,6-dioxo-1,3,7-trihydropurin-7-yl)acetic acid
Appearance: White to off-white powder
Formulation:
CAS Number: 652-37-9
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₉H₁₀N₄O₄
Molecular Weight: 238.2
Cell-Permeable?: True
Purity: ≥ 98%
Solubilities: ~33 mg/ml in DMSO (may need ultrasonication)
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potential Peptidylarginine deiminase (PAD) activator
MDL Number: MFCD00022832
PubChem CID: 69550
SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)O
InChi: InChI=1S/C9H10N4O4/c1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h4H,3H2,1-2H3,(H,14,15)
InChi Key: HCYFGRCYSCXKNQ-UHFFFAOYSA-N