Product Description
AMZ30 is a potent, selective, and covalent inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.
AMZ30 is a potent, selective, and covalent inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.
Biovision | B2714 | AMZ30 DataSheet
Alternate Name/Synonyms: NIH Probe ML136,(E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile
Appearance: Yellow solid
Formulation:
CAS Number: 1313613-09-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₃FN₃O₆S₂
Molecular Weight: 461.44
Cell-Permeable?: TRUE
Purity: ≥98% HPLC
Solubilities: ~ 4 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A protein phosphatase methylesterase-1(PME-1) inhibitor
MDL Number:
PubChem CID: 44607965
SMILES: C1=CC(=CC(=C1)S(=O)(=O)N2C=CC=C2C=C(C#N)S(=O)(=O)C3=CC=C(C=C3)F)[N+](=O)[O-]
InChi: InChI=1S/C19H12FN3O6S2/c20-14-6-8-17(9-7-14)30(26,27)19(13-21)11-15-4-2-10-22(15)31(28,29)18-5-1-3-16(12-18)23(24)25/h1-12H/b19-11+
InChi Key: GUCUORSUHTZMBW-YBFXNURJSA-N