Product Description
Anidulafungin is an echinocandin antifungal drug. It inhibits (1→3)-β-D-glucan synthase which is required for synthesis of the fungal cell wall. It shows potent in vitro activity against Aspergillus and Candida species (MIC₅₀ of 0.03 to 4 μg/ml), including those resistant to fluconazole or amphotericin B. It is effective in treating esophageal candidiasis in clinical trials and has an excellent safety profile.
Anidulafungin is an echinocandin antifungal drug. It inhibits (1→3)-β-D-glucan synthase which is required for synthesis of the fungal cell wall. It shows potent in vitro activity against Aspergillus and Candida species (MIC₅₀ of 0.03 to 4 μg/ml), including those resistant to fluconazole or amphotericin B. It is effective in treating esophageal candidiasis in clinical trials and has an excellent safety profile.
Biovision | B2966 | Anidulafungin DataSheet
Alternate Name/Synonyms: N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl] -11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo [22.3.0.09,13]heptacosan-18-yl]-4-[4-(4-pentoxyphenyl)phenyl]benzamide; Eraxis; Ecalta; LY303366; 1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1':4',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-echinocandin B
Appearance: Solid
Formulation:
CAS Number: 166663-25-8
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₅₈H₇₃N₇O₁₇
Molecular Weight: 1140.24
Cell-Permeable?: False
Purity: ≥95%
Solubilities: ~10 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An antifungal drug that inhibits (1→3)-β-D-glucan synthase
MDL Number: MFCD00917070
PubChem CID: 166548
SMILES: CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O
InChi: InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1
InChi Key: JHVAMHSQVVQIOT-MFAJLEFUSA-N