Product Description
Bisantrene dihydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. It intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin (Cat. No. 1527) in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance
Bisantrene dihydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. It intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin (Cat. No. 1527) in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance
Biovision | B2736 | Bisantrene dihydrochloride DataSheet
Alternate Name/Synonyms: NSC 337766,N-[(E)-[10-[(E)-(4,5-dihydro-1H-imidazol-2-ylhydrazinylidene)methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;dihydrochloride
Appearance: Yellow to orange brown solid
Formulation:
CAS Number: 78186-34-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₄Cl₂N₈
Molecular Weight: 471.39
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~ 2 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An antineoplastic agent and a DNA intercalator
MDL Number: MFCD01743164
PubChem CID: 6917792
SMILES: C1CN=C(N1)NN=CC2=C3C=CC=CC3=C(C4=CC=CC=C42)C=NNC5=NCCN5.Cl.Cl
InChi: InChI=1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;
InChi Key: KINULKKPVJYRON-PVNXHVEDSA-N