Product Description
Bisdemethoxycurcumin is a curcumin analogue with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells and inhibits proliferation of different cell lines at 25 μM. Bisdemethoxycurcumin enhances phagocytosis of amyloid-beta and transcription of MGAT3 and TLR. It down-regulates the transcriptional coactivator p300 and thereby inhibits the Wnt/beta-catenin pathway. It inhibits inducible nitric oxide synthase protein expression and accelerates healing of gastric ulcer in a rat model.
Bisdemethoxycurcumin is a curcumin analogue with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells and inhibits proliferation of different cell lines at 25 μM. Bisdemethoxycurcumin enhances phagocytosis of amyloid-beta and transcription of MGAT3 and TLR. It down-regulates the transcriptional coactivator p300 and thereby inhibits the Wnt/beta-catenin pathway. It inhibits inducible nitric oxide synthase protein expression and accelerates healing of gastric ulcer in a rat model.
Biovision | B2944 | Bisdemethoxycurcumin DataSheet
Alternate Name/Synonyms: (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Didemethoxycurcumin; Curcumin III; Bis(4-hydroxycinnamoyl)methane; Bis(p-hydroxycinnamoyl)methane; Curcuminoid A; Curcumin Lll; DidemethoxycurcumiI; di-p-coumaroylmethane; 1,3-Di(4-hydroxystyryl)propanedial; 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3,6-heptatrien-5-one; BDMC
Appearance: A crystalline solid
Formulation:
CAS Number: 24939-16-0, 33171-05-0
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₉H₁₆O₄
Molecular Weight: 308.33
Cell-Permeable?: True
Purity: >98.0%
Solubilities: ~5 mg/ml in in Ethanol, ~14 mg/ml in DMF in 0, ~10 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A curcumin analogue with anti-inflammatory and anti-proliferative properties
MDL Number:
PubChem CID: 5315472
SMILES: C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
InChi: InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
InChi Key: PREBVFJICNPEKM-YDWXAUTNSA-N