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Product Description
Bobcat339 is a potent cytosine-based TET (ten-eleven translocation methylcytosine dioxygenase) enzyme inhibitor with IC50 of 33 µM (TET1) and 73 µM (TET2). Bobcat339 does not inhibit the DNA methyltransferase, DNMT3a. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.
Bobcat339 is a potent cytosine-based TET (ten-eleven translocation methylcytosine dioxygenase) enzyme inhibitor with IC50 of 33 µM (TET1) and 73 µM (TET2). Bobcat339 does not inhibit the DNA methyltransferase, DNMT3a. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.
Biovision | B3249 | Bobcat339 (free base) DataSheet
Alternate Name/Synonyms: Bobcat-339; 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one
Appearance: White to off-white solid
Formulation:
CAS Number: 2280037-51-4
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₁₆H₁₂ClN₃O
Molecular Weight: 297.74
Cell-Permeable?: True
Purity: ≥ 98%
Solubilities:
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A TET enzyme inhibitor
MDL Number:
PubChem CID: 138319673
SMILES: C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl
InChi: InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21)
InChi Key: QMGYGOOYCNTEQO-UHFFFAOYSA-N
