Product Description
BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM respectively. It shows 50–400 fold selectivity over HDAC3 with an IC₅₀ of 458 nM. Chronic treatment with BRD6929 improves mood-related behaviors in mice.
BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM respectively. It shows 50–400 fold selectivity over HDAC3 with an IC₅₀ of 458 nM. Chronic treatment with BRD6929 improves mood-related behaviors in mice.
Biovision | B2931 | BRD6929 DataSheet
Alternate Name/Synonyms: 4-(Acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-benzamide; Compound 60; TPB; HDAC1 & 2 Inhibitor
Appearance: Solid
Formulation:
CAS Number: 849234-64-6
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₉H₁₇N₃O₂S
Molecular Weight: 351.42
Cell-Permeable?: True
Purity: 97%
Solubilities: 2 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective inhibitor of HDAC1 and 2
MDL Number: MFCD16495786
PubChem CID: 349358485
SMILES: O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3
InChi: InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24)
InChi Key: ABZSPJVXTTUFAA-UHFFFAOYSA-N