Product Description
Carmustine is a nitrogen mustard and a cell-cycle phase nonspecific alkylating antineoplastic agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. It is used in the treatment of brain tumors and various other malignant neoplasms.
Carmustine is a nitrogen mustard and a cell-cycle phase nonspecific alkylating antineoplastic agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. It is used in the treatment of brain tumors and various other malignant neoplasms.
Biovision | B2658 | Carmustine DataSheet
Alternate Name/Synonyms: bis-Chloroethylnitrosourea; N,N'-Bis(2-chloroethyl)-N-nitrosourea; BCNU; Gliadel; NSC 409962
Appearance: Amorphous solid
Formulation:
CAS Number: 154-93-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₅H₉Cl₂N₃O₂
Molecular Weight: 214.05
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~20 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A nitrogen mustard and a DNA alkylating agent
MDL Number: MFCD00057706
PubChem CID: 2578
SMILES: ClCCNC(N(N=O)CCCl)=O
InChi: InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
InChi Key: DLGOEMSEDOSKAD-UHFFFAOYSA-N