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Product Description
A 10 mM (5 mg in 1.48 ml) solution of the JAK inhibitor PF-03394197 (Oclacitinib) in anhydrous DMSO.
PF-03394197 (Oclacitinib) is potent and selective Janus kinase (JAK) inhibitor. It inhibits JAK family members with an IC₅₀ of 10-99 nM being most potent against JAK1 (IC₅₀ = 10 nM). PF-03394197 does not inhibit a panel of 38 non-JAK kinases (IC₅₀ >1 µM). Displays activity against cytokines involved in allergy.
Biovision | B2479 | EZSolution™ PF-03394197 DataSheet
Alternate Name/Synonyms: Oclacitinib, N-Methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide
Appearance: Liquid
Formulation: A 10 mM solution in anhydrous DMSO
CAS Number: 1208319-26-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₂₃N₅O₂S
Molecular Weight: 337.44
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities:
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective JAK inhibitor
MDL Number:
PubChem CID: 44631938
SMILES: CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3
InChi: InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)
InChi Key: HJWLJNBZVZDLAQ-UHFFFAOYSA-N
