Product Description
Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells with an IC₅₀ of 0.6 µM. It suppresses histamine-induced gastric acid secretion in dogs and anesthetized rats with ID₅₀ values of 10 and 400 µg/kg, respectively. It is used to treat ulcers, gastroesophageal reflux disease and heartburn. Famotidine is also being investigated in clinical trials for treatment against COVID-19.
Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells with an IC₅₀ of 0.6 µM. It suppresses histamine-induced gastric acid secretion in dogs and anesthetized rats with ID₅₀ values of 10 and 400 µg/kg, respectively. It is used to treat ulcers, gastroesophageal reflux disease and heartburn. Famotidine is also being investigated in clinical trials for treatment against COVID-19.
Biovision | B3021 | Famotidine DataSheet
Alternate Name/Synonyms: 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide; pepcid; N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine; 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide; (1Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide; MK-208; YM-11170
Appearance: White to Off-White Powder
Formulation:
CAS Number: 76824-35-6
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₈H₁₅N₇O₂S₃
Molecular Weight: 337.45
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~30 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A competitive inhibitor of histamine H2-receptor
MDL Number: MFCD00075320
PubChem CID: 5702160
SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
InChi: InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)
InChi Key: XUFQPHANEAPEMJ-UHFFFAOYSA-N