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Product Description
Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.
G418 sulfate is an aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes.
Biovision | 1557 | G418 Sulfate DataSheet
Alternate Name/Synonyms: Antibiotic G418, G418
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 108321-42-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: Yes
Molecular Formula: C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
Molecular Weight: 692.71
Cell-Permeable?: No
Purity: >720 U/mg (potency)
Solubilities: H₂O (50 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: An antibiotic and a selection agent
MDL Number: MFCD00058314
PubChem CID: 16760463
SMILES: CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
InChi: InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)
InChi Key: UHEPSJJJMTWUCP-UHFFFAOYSA-N
