Product Description
GSK-J2 (sodium salt) is an isomer of GSK-J1. GSK-1 is a selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX, with an IC₅₀ of 60 nM for human JMJD3 in vitro. GSK-J2 poorly inhibits JMJD3 with an IC₅₀ > 100 μM in vitro. GSK-J2 serves as a negative control for in vitro studies with GSK-J1.
GSK-J2 (sodium salt) is an isomer of GSK-J1. GSK-1 is a selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX, with an IC₅₀ of 60 nM for human JMJD3 in vitro. GSK-J2 poorly inhibits JMJD3 with an IC₅₀ > 100 μM in vitro. GSK-J2 serves as a negative control for in vitro studies with GSK-J1.
Biovision | B2813 | GSK-J2 (Sodium Salt) DataSheet
Alternate Name/Synonyms: 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt, 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid;sodium
Appearance: Crystalline solid
Formulation:
CAS Number: 2108665-15-0
Structure Available?: True
Peptide sequence:
Salt Form: True
Molecular Formula: C₂₂H₂₃N₅NaO₂
Molecular Weight: 411.43
Cell-Permeable?: False
Purity: ≥90%
Solubilities: Sparingly soluble in aqueous and organic solvents such as DMSO, ethanol and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A negative control for in vitro studies with GSK-J1
MDL Number:
PubChem CID: 137699749
SMILES: C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CN=CC=C4)NCCC(=O)O.[Na]
InChi: InChI=1S/C22H23N5O2.Na/c28-21(29)7-11-24-19-14-20(26-22(25-19)18-6-3-10-23-15-18)27-12-8-16-4-1-2-5-17(16)9-13-27;/h1-6,10,14-15H,7-9,11-13H2,(H,28,29)(H,24,25,26);
InChi Key: LFPRQFGWKMRKLV-UHFFFAOYSA-N