Product Description
IM156 is a bioenergetic biguanide derivative which blocks mitochondrial complex I and an activator of AMP-activated protein kinase (AMPK). It is a derivative of metformin. IM156 causes energy depletion in tumor cells by inhibiting oxidative phosphorylation. IM156 at a concentration of 15 μM in combination with temozolomide decreases the stemness and invasive properties of glioblastoma tumorspheres. IM156 is in phase I clinical trials for advanced solid tumors and lymphoma.
IM156 is a bioenergetic biguanide derivative which blocks mitochondrial complex I and an activator of AMP-activated protein kinase (AMPK). It is a derivative of metformin. IM156 causes energy depletion in tumor cells by inhibiting oxidative phosphorylation. IM156 at a concentration of 15 μM in combination with temozolomide decreases the stemness and invasive properties of glioblastoma tumorspheres. IM156 is in phase I clinical trials for advanced solid tumors and lymphoma.
Biovision | B3126 | IM156 DataSheet
Alternate Name/Synonyms: HL156A, N'-[N'-[4-(trifluoromethoxy)phenyl]carbamimidoyl]pyrrolidine-1-carboximidamide; N-(Imino((4-(trifluoromethoxy)phenyl)amino)methyl)-1-pyrrolidinecarboximidamide
Appearance: White to off-white solid powder
Formulation:
CAS Number: 1422365-93-2
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₁₃H₁₆F₃N₅O
Molecular Weight: 315.29
Cell-Permeable?: TRUE
Purity: 0.98
Solubilities: 60 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An activator of AMPK and an inhibitor of mitochondrial complex I
MDL Number:
PubChem CID: 71512108
SMILES: C1CCN(C1)C(=NC(=NC2=CC=C(C=C2)OC(F)(F)F)N)N
InChi: InChI=1S/C13H16F3N5O/c14-13(15,16)22-10-5-3-9(4-6-10)19-11(17)20-12(18)21-7-1-2-8-21/h3-6H,1-2,7-8H2,(H4,17,18,19,20)
InChi Key: NGFUHJWVBKTNOE-UHFFFAOYSA-N