Product Description
IOX3 (FG-2216) is a potent, orally bioavailable HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.9 µM for PDH2 enzyme. It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro.
IOX3 (FG-2216) is a potent, orally bioavailable HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.9 µM for PDH2 enzyme. It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro.
Biovision | B2739 | IOX3 (FG-2216) DataSheet
Alternate Name/Synonyms: N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine
Appearance: Crystalline solid
Formulation:
CAS Number: 223387-75-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₂H₉ClN₂O₄
Molecular Weight: 280.7
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~20 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An orally active PHD2 inhibitor
MDL Number:
PubChem CID: 6914666
SMILES: OC1=C(C(NCC(O)=O)=O)N=C(Cl)C2=CC=CC=C21
InChi: InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
InChi Key: OUQVKRKGTAUJQA-UHFFFAOYSA-N