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Product Description
Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan (3 mg/kg) inhibited markers associated with electrical stimulation of the trigeminal ganglion in rodent models of migraine. It is approved for the acute treatment of migraine with or without aura in adults.
Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan (3 mg/kg) inhibited markers associated with electrical stimulation of the trigeminal ganglion in rodent models of migraine. It is approved for the acute treatment of migraine with or without aura in adults.
Biovision | B3032 | Lasmiditan hemisuccinate DataSheet
Alternate Name/Synonyms: Lasmiditan succinate; butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide; 2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hemisuccinate; Butanedioic acid, compd. with 2,4,6-trifluoro-N-(6-((1-methyl-4-piperidinyl)carbonyl)-2-pyridinyl)benzamide (1:2); COL-144; LY573144
Appearance: Solid
Formulation:
CAS Number: 439239-92-6
Structure Available?: TRUE
Peptide sequence:
Salt Form: TRUE
Molecular Formula: C₄₂H₄₂F₆N₆O₈
Molecular Weight: 872.8
Cell-Permeable?: FALSE
Purity: ≥98%
Solubilities: ~9 mg/ml in ethanol, ~14 mg/ml in water, ~100 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A highly selective serotonin 5-HT(1F) receptor agonist
MDL Number: MFCD31728527
PubChem CID: 46927777
SMILES: CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.C(CC(=O)O)C(=O)O
InChi: InChI=1S/2C19H18F3N3O2.C4H6O4/c2*1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22;5-3(6)1-2-4(7)8/h2*2-4,9-11H,5-8H2,1H3,(H,23,24,27);1-2H2,(H,5,6)(H,7,8)
InChi Key: MSOIHUHNGPOCTH-UHFFFAOYSA-N
