Product Description
NCC007 is an inhibitor of casein kinase I (CKI) and a modulator of circadian rhythm. It inhibits CKIα and CKIδ with an IC₅₀ of 1.8 and 3.6 μM. It shows stronger period effects (0.32 μM for 5 h period lengthening) in a cell-based circadian assay.
NCC007 is an inhibitor of casein kinase I (CKI) and a modulator of circadian rhythm. It inhibits CKIα and CKIδ with an IC₅₀ of 1.8 and 3.6 μM. It shows stronger period effects (0.32 μM for 5 h period lengthening) in a cell-based circadian assay.
Biovision | B3139 | NCC007 DataSheet
Alternate Name/Synonyms: 9-(1-cyclopropylethyl)-2-N-[2-(dimethylamino)ethyl]-6-N-[[3-(trifluoromethyl)phenyl]methyl]purine-2,6-diamine
Appearance: White to off-white solid
Formulation:
CAS Number: 2342583-66-6
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₂₂H₂₈F₃N₇
Molecular Weight: 447.5
Cell-Permeable?: TRUE
Purity: ≥ 98%
Solubilities: ~115 mg/ml in DMSO (may need ultrasonication)
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of CKI and a modulator of circadian rhythm
MDL Number: MFCD32067989
PubChem CID: 138403252
SMILES: CC(C1CC1)N2C=NC3=C(N=C(N=C32)NCCN(C)C)NCC4=CC(=CC=C4)C(F)(F)F
InChi: InChI=1S/C22H28F3N7/c1-14(16-7-8-16)32-13-28-18-19(29-21(30-20(18)32)26-9-10-31(2)3)27-12-15-5-4-6-17(11-15)22(23,24)25/h4-6,11,13-14,16H,7-10,12H2,1-3H3,(H2,26,27,29,30)
InChi Key: GHRNSZVMIARHIS-UHFFFAOYSA-N