Euro
USD
British Pound
NULL
Product Description
Neoseptin-3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist (EC50 of 18.5 μM). Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (mTLR) independently of CD14 (cluster of differentiation 14). Neoseptin-3 binds to MD2, changes the conformation of MD-2 and facilitates active TLR4/MD-2 dimer formation.
Neoseptin-3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist (EC50 of 18.5 μM). Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (mTLR) independently of CD14 (cluster of differentiation 14). Neoseptin-3 binds to MD2, changes the conformation of MD-2 and facilitates active TLR4/MD-2 dimer formation.
Biovision | B2756 | Neoseptin-3 DataSheet
Alternate Name/Synonyms: (αS)-α-[[4-Amino-3-[2-(4-hydroxyphenyl)ethyl]benzoyl]amino]-benzenebutanoic acid 1,1-dimethylethyl ester
Appearance: White to off-white solid
Formulation:
CAS Number: 1622863-21-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₃₄N₂O₄
Molecular Weight: 474.59
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: ~15 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A specific agonist of the mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (MD-2) complex
MDL Number:
PubChem CID: 375690552
SMILES: O=C(OC(C)(C)C)[C@@H](NC(C1=CC=C(N)C(CCC2=CC=C(O)C=C2)=C1)=O)CCC3=CC=CC=C3
InChi: InChI=1S/C29H34N2O4/c1-29(2,3)35-28(34)26(18-12-20-7-5-4-6-8-20)31-27(33)23-14-17-25(30)22(19-23)13-9-21-10-15-24(32)16-11-21/h4-8,10-11,14-17,19,26,32H,9,12-13,18,30H2,1-3H3,(H,31,33)/t26-/m0/s1
InChi Key: OACODUCFPHHCIH-SANMLTNESA-N
