Euro
USD
British Pound
NULL
Product Description
A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
Niclosamide is a STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
Biovision | 1826 | Niclosamide DataSheet
Alternate Name/Synonyms: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Appearance: Off-white to pale yellow solid
Formulation: N/A
CAS Number: 50-65-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₃H₈Cl₂N₂O₄
Molecular Weight: 327.12
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (10 mM) or Ethanol (25 mM)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A STAT3 signaling pathway inhibitor
MDL Number: MFCD00057597
PubChem CID: 4477
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChi: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChi Key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
