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Product Description
SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag. It is a photoreactive “clickable“ probe. It is used to profile histone deacetylase (HDAC) activities in native proteomes and live cells. It labels HDAC complex proteins in proteomes at 100 nM and in live cells at 500 nM. It shows an IC₅₀ value of ~3 μM for inhibiting HDAC activity in HeLa cell nuclear lysates.
SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag. It is a photoreactive “clickable“ probe. It is used to profile histone deacetylase (HDAC) activities in native proteomes and live cells. It labels HDAC complex proteins in proteomes at 100 nM and in live cells at 500 nM. It shows an IC₅₀ value of ~3 μM for inhibiting HDAC activity in HeLa cell nuclear lysates.
Biovision | B2840 | SAHA-Bpyne DataSheet
Alternate Name/Synonyms: Click Tag™ SAHA-Bpyne; Suberoylanilide Hydroxamic Acid-Bpyne; N1-hydroxy-N8-[4-[4-[(1-oxo-5-hexyn-1-yl)amino]benzoyl]phenyl]-octanediamide
Appearance:
Formulation: A solution in methanol
CAS Number: 930772-88-6
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₂₇H₃₁N₃O₅
Molecular Weight: 477.6
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~5 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A SAHA derivative with a click tag
MDL Number:
PubChem CID: 90276494
SMILES: O=C(CCCCCCC(NO)=O)NC1=CC=C(C(C2=CC=C(NC(CCCC#C)=O)C=C2)=O)C=C1
InChi: InChI=1S/C27H31N3O5/c1-2-3-6-9-24(31)28-22-16-12-20(13-17-22)27(34)21-14-18-23(19-15-21)29-25(32)10-7-4-5-8-11-26(33)30-35/h1,12-19,35H,3-11H2,(H,28,31)(H,29,32)(H,30,33)
InChi Key: VHTATGLVGGHVIS-UHFFFAOYSA-N
