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Product Description
SAR-125844 is a potent, selective, reversible and ATP-competitive c-MET inhibitor, with an IC₅₀ of 4.2 nM. Displays inhibition of MET autophosphorylation in cell-based assays. Upon intravenous administration, SAR-125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways.This may result in cell growth inhibition in tumors that overexpress c-Met.
SAR-125844 is a potent, selective, reversible and ATP-competitive c-MET inhibitor, with an IC₅₀ of 4.2 nM. Displays inhibition of MET autophosphorylation in cell-based assays. Upon intravenous administration, SAR-125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways.This may result in cell growth inhibition in tumors that overexpress c-Met.
Biovision | B2510 | SAR-125844 DataSheet
Alternate Name/Synonyms: SAR125844; 1-(6-((6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea
Appearance: Crystalline solid
Formulation:
CAS Number: 1116743-46-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: Yes
Molecular Formula: C₂₅H₂₃FN₈O₂S₂
Molecular Weight: 550.63
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >40 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent c-Met inhibitor
MDL Number:
PubChem CID: 25182860
SMILES: C1COCCN1CCNC(=O)NC2=NC3=C(S2)C=C(C=C3)SC4=NN=C5N4N=C(C=C5)C6=CC=C(C=C6)F
InChi: InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35)
InChi Key: ODIUNTQOXRXOIV-UHFFFAOYSA-N
