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Product Description
SB-225002 is a potent and selective inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2; displays > 150-fold selectivity over CXCR1 receptors. SB-225002 is crucial for cancer progression and is involved in inflammatory diseases like COPD, rheumatoid arthritis, and ulcerative colitis.
SB-225002 is a potent and selective inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2; displays > 150-fold selectivity over CXCR1 receptors. SB-225002 is crucial for cancer progression and is involved in inflammatory diseases like COPD, rheumatoid arthritis, and ulcerative colitis.
Biovision | B3282 | SB-225002 DataSheet
Alternate Name/Synonyms: N-(2-Hydroxy-4-nitrophenyl)-N′-(2-bromophenyl)urea SB225002
Appearance: Yellow solid
Formulation:
CAS Number: 182498-32-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₃H₁₀BrN₃O₄
Molecular Weight: 352.14
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >30 mg/ml DMSO >15 mg/ml Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent nonpeptide inhibitor of chemokine receptor CXCR2
MDL Number:
PubChem CID: 3854666
SMILES: C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
InChi: InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChi Key: MQBZVUNNWUIPMK-UHFFFAOYSA-N
